Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38? mitogen-activated protein kinase.

Source:http://linkedlifedata.com/resource/pubmed/id/21375264

J. Med. Chem. 2011 Apr 14 54 7 2255-65

Download in:

View as

General Info

PMID
21375264